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Brain Research Institute

Laboratory of Neural Plasticity

We use a multi-pronged, interdisciplinary approach to study the molecular and cellular framework of neural stem cell (NSC) biology in the developing and adult brain. Aim of our research is to understand how physiologic and disease-associated alterations of neurogenesis are translated into stem cell-associated plastic changes in the brain on a molecular, cellular, and behavioral level. For details please refer toResearch Interests


Sebastian Jessberger is Professor for Neurosciences and Director of the Brain Research Institute. He studied Medicine in Hamburg, Germany and carried out his medical thesis at the Center for Molecular Neurobiology (ZMNH) in Hamburg. In 2002 he started a joint residency in the laboratory of Gerd Kempermann at the Max Delbruck Center for Molecular Medicine (MDC) and the Dept. of Neurology of the Charité University Hospital in Berlin, Germany. As a postdoctoral fellow (2004-2007) in the laboratory of Fred H. Gage at the Salk Institute for Biological Studies in La Jolla, USA he continued to work on neural stem cell biology and neurogenesis in the adult brain. From 2007 to 2012 he was Assistant Professor at the ETH Zurich and joined the Brain Research Institute in August 2012.He received various prizes (e.g., Max Cloëtta Foundation award 2023, Robert Bing prize 2016, Friedrich Götz prize 2013) and was awarded to join the EMBO Young Investigator program in 2012. He obtained several ERC/SNSF replacement grants (CoG "METABO-STEM" 2015, "STEMBAR" 2016; AdG "AgeTrack" 2022).

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