Laboratory of Neural Connectivity

Our ability to perceive and shape the world around us is determined by the neural circuits in our brains. Neural circuits form during development, but contrary to traditional assumptions, it is becoming clear that neural circuits can also form in the adult brain. How is this possible, and what can the new circuits do? Exploring these questions inevitably leads to the more fundamental question of how brain circuits are maintained throughout life.

Our research focuses on these open questions by studying neuron rewiring in the adult brain. We are investigating molecular mechanisms that can reactivate axon growth in adult neurons, a critical first step in circuit formation. In addition, we are studying the properties of the new circuits and their effects on brain function. Based on these findings, we are also investigating the mechanisms that maintain the remarkable integrity of neural circuits throughout life and their potential dysfunction in brain disease and aging.

Csaba Földy is an Associate Professor and Co-Director of the Brain Research Institute. He received his Ph.D. in Neuroscience from UC Irvine, and completed his postdoctoral training with Tom Südhof and Rob Malenka at Stanford University, before moving to Zürich.